Document 3003
 DOCN  M94A3003
 TI    HIV-related non Hodgkin lymphomas (NHL): report of 53 cases.
 DT    9412
 AU    Schlacht I; Landonio G; Nosari AM; Caggese L; Orso M; Schiantarelli C;
       Dept. of Infectious Diseases, Niguarda Hospital, Milan, Italy.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):176 (abstract no. PB0129). Unique
       Identifier : AIDSLINE ICA10/94369572
 AB    OBJECTIVE: to evaluate retrospectively 53 cases of HIV-related NHL,
       followed in our Department in the period 1986-1993. ANALYSIS OF CASES:
       43 were males, 10 females. Median age was 30 yrs (r. 26-54). CD4+ were <
       0.1 x 10E9 g/l in 43 cases; at diagnosis opportunistic infections were
       present in 37 cases. 23 (43%) were primary cerebral lymphomas (PCL);
       only 10 (19%) were lymphonodal at onset; 20 (38%) were extranodal (4
       cutaneous, 3 lungs, 2 bone marrow, 2 gastroenteric, 1 breast, 1 tongue,
       7 plurivisceral). The diagnosis was bioptic in 24 cases; autoptic in 29
       (20/23 PCL). Histology, according to WF: high malignancy in all PCL; in
       other cases: 22 high (4 G, 3 H, 1 I, 1 J, 9 K, 4 Ki-1) and 8
       low-intermediate malignancy (2 C, 4 F, 1 AILD-T, 1 T cutaneous). 50/53
       cases showed B immunophenotype. Median follow-up was 5 months (r: 1-38).
       Only 9 patients are still alive. Median overall survival (MOS) was 2
       months in PCL (r: 1-4) and 7 months in other cases (r. 1-38).
       Chemotherapy (CHOP cycles) was performed in 14 cases (MOS of treated
       patients: 7 months); radiotherapy in 7 (6/7 PCL). 1 patient had
       associated Kaposi's Sarcoma. CONCLUSION: 1) PCL were the most frequent
       sites of onset of HIV-related NHL; 2) other extranodal lymphomas were
       very frequent, with some unusual sites of onset (breast, tongue); 3)
       histology was high malignancy in a high percentage of cases (84%); 4)
       the course was aggressive in the majority; MOS was low even in treated
       patients; longer survival was seen only in low-intermediate malignancy.
 DE    Adult  AIDS-Related Opportunistic Infections/DIAGNOSIS/MORTALITY/THERAPY
       Brain Neoplasms/DIAGNOSIS/MORTALITY/THERAPY  Combined Modality Therapy
       Female  Follow-Up Studies  Human  HIV
       Infections/*DIAGNOSIS/MORTALITY/THERAPY  Lymphoma,
       AIDS-Related/*DIAGNOSIS/MORTALITY/THERAPY  Male  Middle Age
       Retrospective Studies  Survival Rate  MEETING ABSTRACT

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).